Waters Synapt-G2 HDMS
The Synapt G2 is an ion mobility/mass spectrometry (IM/MS)
instrument equipped with an electrospray-ionization source. The
instrument can be operated in the IM/MS and in the MS only mode.
After ion generation by electrospray, parent ions can be
selected by using a quadrupole mass filter. In the IM/MS mode,
the ions first are collected in an argon-filled trapping area as
part of the stacked ring ion guide (SRIG) called Trap directly
located in front of the ion-mobility analyzer. The first part of
the ion-mobility separation SRIG is filled with He to alleviate
the transfer of the pulsed in ion bunch from the trap to the
Ion-Mobility Separator whose major part is filled with nitrogen.
According to their ion-cross sections ions having the same
nominal mass are separated by their different drift times. After
passing through the SRIG called Transfer the ions are mass
analyzed by a reflectron time-of-flight mass spectrometer having
a mass resolution up to 40000 (50% valley definition). In
addition, ion-molecule reactions can be studied by using the
trap, IM and/or the transfer cell as reaction cells,
respectively. To this end, the instrument has been modified and
equipped with a series of mass-flow controllers by which various
neutral substrates can be leaked into the individual regions.